Stability of Maleimide-PEG and Mono-Sulfone-PEG Conjugation to a Novel Engineered Cysteine in the Human Hemoglobin Alpha Subunit

In order to use a Hemoglobin Based Oxygen Carrier as an oxygen therapeutic or blood substitute, it is necessary to increase the size of the hemoglobin molecule to prevent rapid renal clearance. A common method uses maleimide PEGylation of sulfhydryls created by the reaction of 2-iminothiolane at sur...

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Detalles Bibliográficos
Autores principales: Cooper, Chris E., Bird, Matthew, Sheng, XiaoBo, Choi, Ji-Won, Silkstone, Gary G.A., Simons, Michelle, Syrett, Natalie, Piano, Riccardo, Ronda, Luca, Bettati, Stefano, Paredi, Gianluca, Mozzarelli, Andrea, Reeder, Brandon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350135/
https://www.ncbi.nlm.nih.gov/pubmed/34381760
http://dx.doi.org/10.3389/fchem.2021.707797

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350135/
https://www.ncbi.nlm.nih.gov/pubmed/34381760
http://dx.doi.org/10.3389/fchem.2021.707797

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