Mycobacterium tuberculosis Phosphoribosyltransferase Promotes Bacterial Survival in Macrophages by Inducing Histone Hypermethylation in Autophagy-Related Genes

Mycobacterium tuberculosis (Mtb) inhibits autophagy to promote its survival in host cells. However, the molecular mechanisms by which Mtb inhibits autophagy are poorly understood. Here, we report a previously unknown mechanism in which Mtb phosphoribosyltransferase (MtbPRT) inhibits autophagy in an...

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Detalles Bibliográficos
Autores principales: Sengupta, Srabasti, Nayak, Barsa, Meuli, Michael, Sander, Peter, Mishra, Snehasish, Sonawane, Avinash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350138/
https://www.ncbi.nlm.nih.gov/pubmed/34381738
http://dx.doi.org/10.3389/fcimb.2021.676456

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350138/
https://www.ncbi.nlm.nih.gov/pubmed/34381738
http://dx.doi.org/10.3389/fcimb.2021.676456

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