Specific amino acid supplementation rescues the heart from lipid overload-induced insulin resistance and contractile dysfunction by targeting the endosomal mTOR–v-ATPase axis

OBJECTIVE: The diabetic heart is characterized by extensive lipid accumulation which often leads to cardiac contractile dysfunction. The underlying mechanism involves a pivotal role for vacuolar-type H(+)-ATPase (v-ATPase, functioning as endosomal/lysosomal proton pump). Specifically, lipid oversupp...

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Detalles Bibliográficos
Autores principales: Wang, Shujin, Schianchi, Francesco, Neumann, Dietbert, Wong, Li-Yen, Sun, Aomin, van Nieuwenhoven, Frans A., Zeegers, Maurice P., Strzelecka, Agnieszka, Col, Umare, Glatz, Jan F.C., Nabben, Miranda, Luiken, Joost J.F.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350375/
https://www.ncbi.nlm.nih.gov/pubmed/34265467
http://dx.doi.org/10.1016/j.molmet.2021.101293

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350375/
https://www.ncbi.nlm.nih.gov/pubmed/34265467
http://dx.doi.org/10.1016/j.molmet.2021.101293

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