Cargando…

Specific amino acid supplementation rescues the heart from lipid overload-induced insulin resistance and contractile dysfunction by targeting the endosomal mTOR–v-ATPase axis

OBJECTIVE: The diabetic heart is characterized by extensive lipid accumulation which often leads to cardiac contractile dysfunction. The underlying mechanism involves a pivotal role for vacuolar-type H(+)-ATPase (v-ATPase, functioning as endosomal/lysosomal proton pump). Specifically, lipid oversupp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Shujin, Schianchi, Francesco, Neumann, Dietbert, Wong, Li-Yen, Sun, Aomin, van Nieuwenhoven, Frans A., Zeegers, Maurice P., Strzelecka, Agnieszka, Col, Umare, Glatz, Jan F.C., Nabben, Miranda, Luiken, Joost J.F.P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350375/ https://www.ncbi.nlm.nih.gov/pubmed/34265467 http://dx.doi.org/10.1016/j.molmet.2021.101293

Ejemplares similares

Augmenting Vacuolar H(+)-ATPase Function Prevents Cardiomyocytes from Lipid-Overload Induced Dysfunction
por: Wang, Shujin, et al.
Publicado: (2020)

Ketone Body Exposure of Cardiomyocytes Impairs Insulin Sensitivity and Contractile Function through Vacuolar-Type H(+)-ATPase Disassembly—Rescue by Specific Amino Acid Supplementation
por: Wang, Shujin, et al.
Publicado: (2022)

Endosomal v-ATPase as a Sensor Determining Myocardial Substrate Preference
por: Wang, Shujin, et al.
Publicado: (2022)

CD36 (SR-B2) as a Target to Treat Lipid Overload-Induced Cardiac Dysfunction
por: Glatz, Jan F.C., et al.
Publicado: (2020)

CD36 (SR-B2) as master regulator of cellular fatty acid homeostasis
por: Glatz, Jan F.C., et al.
Publicado: (2022)

Putative Role of Protein Palmitoylation in Cardiac Lipid-Induced Insulin Resistance
por: Schianchi, Francesco, et al.
Publicado: (2020)

Metabolic Interventions to Prevent Hypertrophy-Induced Alterations in Contractile Properties In Vitro
por: Geraets, Ilvy M. E., et al.
Publicado: (2021)

Re-balancing cellular energy substrate metabolism to mend the failing heart(☆)
por: Glatz, Jan F.C., et al.
Publicado: (2019)

Acute and Chronic Effects of Protein Kinase-D Signaling on Cardiac Energy Metabolism
por: Simsek Papur, Ozlenen, et al.
Publicado: (2018)

Fluorescent labelling of membrane fatty acid transporter CD36 (SR-B2) in the extracellular loop
por: Liu, Yilin, et al.
Publicado: (2019)

Phosphatidylinositol 4-kinase IIIβ mediates contraction-induced GLUT4 translocation and shows its anti-diabetic action in cardiomyocytes
por: Sun, A., et al.
Publicado: (2020)

Microbial-Driven Butyrate Regulates Jejunal Homeostasis in Piglets During the Weaning Stage
por: Zhong, Xi, et al.
Publicado: (2019)

Assessing fatty acid oxidation flux in rodent cardiomyocyte models
por: Rech, M., et al.
Publicado: (2018)

Glycolaldehyde-modified proteins cause adverse functional and structural aortic remodeling leading to cardiac pressure overload
por: Haesen, Sibren, et al.
Publicado: (2020)

Protein-mediated Fatty Acid Uptake in the Heart
por: Chabowski, Adrian, et al.
Publicado: (2008)

Fatty Acids Prevent Hypoxia-Inducible Factor-1α Signaling Through Decreased Succinate in Diabetes
por: Dodd, Michael S., et al.
Publicado: (2018)

Inhibition of sarcolemmal FAT/CD36 by sulfo-N-succinimidyl oleate rapidly corrects metabolism and restores function in the diabetic heart following hypoxia/reoxygenation
por: Mansor, Latt S., et al.
Publicado: (2017)

A new set of reference housekeeping genes for the normalization RT-qPCR data from the intestine of piglets during weaning
por: Wang, Shujin, et al.
Publicado: (2018)

Regulation of Cardiac Contractility by the Alpha 2 Subunit of the Na(+)/K(+)-ATPase
por: Skogestad, Jonas, et al.
Publicado: (2022)

Impact of gender on contractile function in human skinned fibers in condition of volume-overload
por: Bening, Constanze, et al.
Publicado: (2015)

Effects of Iron Overload on the Activity of Na,K-ATPase and Lipid Profile of the Human Erythrocyte Membrane
por: Sousa, Leilismara, et al.
Publicado: (2015)

Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase
por: Gidon, Alexandre, et al.
Publicado: (2014)

Special Issue-articles on “Cellular Lipid Binding Proteins”
por: Glatz, Jan F.C.
Publicado: (2007)

Effects of Trandolapril on Structural, Contractile and Electrophysiological Remodeling in Experimental Volume Overload Heart Failure
por: Jarkovská, Dagmar, et al.
Publicado: (2021)

Neutral sphingomyelinase 2 controls exosome secretion by counteracting V-ATPase-mediated endosome acidification
por: Choezom, Dolma, et al.
Publicado: (2022)

Contractile deficits in engineered cardiac microtissues as a result of MYBPC3 deficiency and mechanical overload
por: Ma, Zhen, et al.
Publicado: (2018)

Regulators of Vps4 ATPase Activity at Endosomes Differentially Influence the Size and Rate of Formation of Intralumenal Vesicles
por: Nickerson, Daniel P., et al.
Publicado: (2010)

Cholesterol Overload: Contact Sites to the Rescue!
por: Enrich, Carlos, et al.
Publicado: (2019)

Cardiac contractile dysfunction in insulin-resistant rats fed a high-fat diet is associated with elevated CD36-mediated fatty acid uptake and esterification
por: Ouwens, D. M., et al.
Publicado: (2007)

Low-intensity pulsed ultrasound enhances angiogenesis and ameliorates contractile dysfunction of pressure-overloaded heart in mice
por: Ogata, Tsuyoshi, et al.
Publicado: (2017)

Loss of cardiac myosin light chain kinase contributes to contractile dysfunction in right ventricular pressure overload
por: Prasad, Vidhya, et al.
Publicado: (2022)

Spectrophotometric Studies on Intact Muscle : II. Recovery from contractile activity
por: Jöbsis, Frans F.
Publicado: (1963)

Apical endosomes isolated from kidney collecting duct principal cells lack subunits of the proton pumping ATPase
Publicado: (1992)

Ubiquitination of the N-terminal Region of Caveolin-1 Regulates Endosomal Sorting by the VCP/p97 AAA-ATPase
por: Kirchner, Philipp, et al.
Publicado: (2013)

Extracellular and Luminal pH Regulation by Vacuolar H(+)-ATPase Isoform Expression and Targeting to the Plasma Membrane and Endosomes
por: Smith, Gina A., et al.
Publicado: (2016)

Myocyte contractility can be maintained by storing cells with the myosin ATPase inhibitor 2,3 butanedione monoxime
por: Chung, Charles S, et al.
Publicado: (2015)

Knockout of the ATPase inhibitory factor 1 protects the heart from pressure overload-induced cardiac hypertrophy
por: Yang, Kevin, et al.
Publicado: (2017)

Myocardial work index: a marker of left ventricular contractility in pressure‐ or volume overload‐induced heart failure
por: Lakatos, Bálint Károly, et al.
Publicado: (2021)

Novel Genes Involved in Endosomal Traffic in Yeast Revealed by Suppression of a Targeting-defective Plasma Membrane ATPase Mutant
por: Luo, Wen-jie, et al.
Publicado: (1997)

Collapse of late endosomal pH elicits a rapid Rab7 response via V-ATPase and RILP
por: Mulligan, R.J., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_k882nrm8r796t9tmfn1t4rch11