CHIP-dependent regulation of the actin cytoskeleton is linked to neuronal cell membrane integrity

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CHIP is an E3-ubiquitin ligase that contributes to healthy aging and has been characterized as neuroprotective. To elucidate dominant CHIP-dependent changes in protein steady-state levels in a patient-derived human neuronal model, CHIP function was ablated using gene-editing and an unbiased proteomi...

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Detalles Bibliográficos
Autores principales: Dias, Catarina, Nita, Erisa, Faktor, Jakub, Tynan, Ailish C., Hernychova, Lenka, Vojtesek, Borivoj, Nylandsted, Jesper, Hupp, Ted R., Kunath, Tilo, Ball, Kathryn L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350547/
https://www.ncbi.nlm.nih.gov/pubmed/34401662
http://dx.doi.org/10.1016/j.isci.2021.102878

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8350547/
https://www.ncbi.nlm.nih.gov/pubmed/34401662
http://dx.doi.org/10.1016/j.isci.2021.102878

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