A Phase 1 first‐in‐human study of the safety, tolerability, and pharmacokinetics of the ROBO2 fusion protein PF‐06730512 in healthy participants

Proteinuria associated with podocyte effacement is a hallmark of focal segmental glomerulosclerosis (FSGS). Preclinical studies implicated ROBO2/SLIT2 signaling in the regulation of podocyte adhesion, and inhibition of this pathway is a novel target to slow FSGS disease progression. This first‐in‐hu...

Descripción completa

Detalles Bibliográficos
Autores principales: Lim, Chay Ngee, Kantaridis, Constantino, Huyghe, Isabelle, Gorman, Donal, Berasi, Stephen, Sonnenberg, Gabriele E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351251/
https://www.ncbi.nlm.nih.gov/pubmed/34369667
http://dx.doi.org/10.1002/prp2.813

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351251/
https://www.ncbi.nlm.nih.gov/pubmed/34369667
http://dx.doi.org/10.1002/prp2.813

Ejemplares similares