LMD-03. Single cell analysis reveals how therapy remodels the tumor microenvironment in melanoma CNS metastases and uncovers a novel predictor of improved survival

We interrogated the microenvironment of 43 clinical samples from melanoma skin, brain (MBM) and leptomeningeal metastases (LMM) using single-cell RNA-seq analysis to determine how therapeutic intervention shaped the immune environment and affected patient survival. LMM is a poorly-characterized, dev...

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Detalles Bibliográficos
Autores principales: Smalley, Inna, Chen, Zhihua, Phadke, Manali, Li, Jiannong, Yu, Xiaoqing, Wyatt, Clayton, Evernden, Brittany, Messina, Jane, Sarnaik, Amod, Sondak, Vernon, Zhang, Chaomei, Law, Vincent, Tran, Nam, Etame, Arnold, Macaulay, Robert, Eroglu, Zaynep, Forsyth, Peter, Rodriguez, Paulo, Chen, Ann, Smalley, Keiran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Supplement Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351302/
http://dx.doi.org/10.1093/noajnl/vdab071.028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351302/
http://dx.doi.org/10.1093/noajnl/vdab071.028

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