Treatment-induced arteriolar revascularization and miR-126 enhancement in bone marrow niche protect leukemic stem cells in AML

BACKGROUND: During acute myeloid leukemia (AML) growth, the bone marrow (BM) niche acquires significant vascular changes that can be offset by therapeutic blast cytoreduction. The molecular mechanisms of this vascular plasticity remain to be fully elucidated. Herein, we report on the changes that oc...

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Detalles Bibliográficos
Autores principales: Zhang, Bin, Nguyen, Le Xuan Truong, Zhao, Dandan, Frankhouser, David E., Wang, Huafeng, Hoang, Dinh Hoa, Qiao, Junjing, Abundis, Christina, Brehove, Matthew, Su, Yu-Lin, Feng, Yuxin, Stein, Anthony, Ghoda, Lucy, Dorrance, Adrianne, Perrotti, Danilo, Chen, Zhen, Han, Anjia, Pichiorri, Flavia, Jin, Jie, Jovanovic-Talisman, Tijana, Caligiuri, Michael A., Kuo, Calvin J., Yoshimura, Akihiko, Li, Ling, Rockne, Russell C., Kortylewski, Marcin, Zheng, Yi, Carlesso, Nadia, Kuo, Ya-Huei, Marcucci, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351342/
https://www.ncbi.nlm.nih.gov/pubmed/34372909
http://dx.doi.org/10.1186/s13045-021-01133-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351342/
https://www.ncbi.nlm.nih.gov/pubmed/34372909
http://dx.doi.org/10.1186/s13045-021-01133-y

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