The DNA methylation landscape of multiple myeloma shows extensive inter- and intrapatient heterogeneity that fuels transcriptomic variability

BACKGROUND: Cancer evolution depends on epigenetic and genetic diversity. Historically, in multiple myeloma (MM), subclonal diversity and tumor evolution have been investigated mostly from a genetic perspective. METHODS: Here, we performed an analysis of 42 MM samples from 21 patients by using enhan...

Descripción completa

Detalles Bibliográficos
Autores principales: Derrien, Jennifer, Guérin-Charbonnel, Catherine, Gaborit, Victor, Campion, Loïc, Devic, Magali, Douillard, Elise, Roi, Nathalie, Avet-Loiseau, Hervé, Decaux, Olivier, Facon, Thierry, Mallm, Jan-Philipp, Eils, Roland, Munshi, Nikhil C., Moreau, Philippe, Herrmann, Carl, Magrangeas, Florence, Minvielle, Stéphane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351364/
https://www.ncbi.nlm.nih.gov/pubmed/34372935
http://dx.doi.org/10.1186/s13073-021-00938-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351364/
https://www.ncbi.nlm.nih.gov/pubmed/34372935
http://dx.doi.org/10.1186/s13073-021-00938-3

Ejemplares similares