Cargando…

ME2 Promotes Proneural–Mesenchymal Transition and Lipogenesis in Glioblastoma

Malic enzyme 2 (ME2) catalyzes the formation of pyruvate from malic acid and is abnormally expressed in some tumors. However, the exact effects of ME2 on proneural–mesenchymal transition (PMT) and lipogenesis in glioblastoma multiforme (GBM) remain unexplored. Here, we found that ME2 expression was...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Mengting, Chen, Xi, Zhang, Junyao, Xiong, Ermeng, Wang, Qianqian, Fang, Wenjing, Li, Li, Fei, Fei, Gong, Aihua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351415/ https://www.ncbi.nlm.nih.gov/pubmed/34381734 http://dx.doi.org/10.3389/fonc.2021.715593

Ejemplares similares

A Voxel-Based Radiographic Analysis Reveals the Biological Character of Proneural-Mesenchymal Transition in Glioblastoma
por: Qi, Tengfei, et al.
Publicado: (2021)

ALKBH5-PYCR2 Positive Feedback Loop Promotes Proneural-Mesenchymal Transition Via Proline Synthesis In GBM
por: Li, Li, et al.
Publicado: (2023)

Proneural-Mesenchymal Transition: Phenotypic Plasticity to Acquire Multitherapy Resistance in Glioblastoma
por: Fedele, Monica, et al.
Publicado: (2019)

Altered cytoskeletal status in the transition from proneural to mesenchymal glioblastoma subtypes
por: Keller, Maureen, et al.
Publicado: (2022)

Monocyte depletion enhances neutrophil influx and proneural to mesenchymal transition in glioblastoma
por: Chen, Zhihong, et al.
Publicado: (2023)

Angiogenic Gene Signature Derived from Subtype Specific Cell Models Segregate Proneural and Mesenchymal Glioblastoma
por: Sharma, Aman, et al.
Publicado: (2017)

USP10 deubiquitinates RUNX1 and promotes proneural-to-mesenchymal transition in glioblastoma
por: Qiu, Wenjin, et al.
Publicado: (2023)

Crosstalk between glioblastoma and tumor microenvironment drives proneural–mesenchymal transition through ligand-receptor interactions
por: Lai, Yancheng, et al.
Publicado: (2023)

RBPJ contributes to the malignancy of glioblastoma and induction of proneural‐mesenchymal transition via IL‐6‐STAT3 pathway
por: Zhang, Guangtao, et al.
Publicado: (2020)

Mesenchymal and Proneural Subtypes of Glioblastoma Disclose Branching Based on GSC Associated Signature
por: Steponaitis, Giedrius, et al.
Publicado: (2021)

Molecular mechanism by which CDCP1 promotes proneural-mesenchymal transformation in primary glioblastoma
por: Lin, Zhiying, et al.
Publicado: (2022)

Nattokinase crude extract enhances oral mucositis healing
por: Zhang, Junyao, et al.
Publicado: (2021)

PDIA3P1 promotes Temozolomide resistance in glioblastoma by inhibiting C/EBPβ degradation to facilitate proneural-to-mesenchymal transition
por: Gao, Zijie, et al.
Publicado: (2022)

Coexpression analysis of CD133 and CD44 identifies Proneural and Mesenchymal subtypes of glioblastoma multiforme
por: Brown, Daniel V., et al.
Publicado: (2015)

Human Mesenchymal glioblastomas are characterized by an increased immune cell presence compared to Proneural and Classical tumors
por: Kaffes, Ioannis, et al.
Publicado: (2019)

A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma
por: Stringer, Brett W., et al.
Publicado: (2019)

EGFRvIII Promotes the Proneural–Mesenchymal Transition of Glioblastoma Multiforme and Reduces Its Sensitivity to Temozolomide by Regulating the NF-κB/ALDH1A3 Axis
por: Shi, Zhong-Fang, et al.
Publicado: (2023)

Higher vascularity at infiltrated peripheral edema differentiates proneural glioblastoma subtype
por: Chelebian, Eduard, et al.
Publicado: (2020)

CDK4/6 inhibition is more active against the glioblastoma proneural subtype
por: Li, Ming, et al.
Publicado: (2017)

Metabolic Heterogeneity of Brain Tumor Cells of Proneural and Mesenchymal Origin
por: Seliger, Corinna, et al.
Publicado: (2022)

Multifaceted WNT Signaling at the Crossroads Between Epithelial-Mesenchymal Transition and Autophagy in Glioblastoma
por: Coelho, Bárbara Paranhos, et al.
Publicado: (2020)

Publisher Correction: A reference collection of patient-derived cell line and xenograft models of proneural, classical and mesenchymal glioblastoma
por: Stringer, Brett W., et al.
Publicado: (2020)

Glioblastoma Models Reveal the Connection between Adult Glial Progenitors and the Proneural Phenotype
por: Lei, Liang, et al.
Publicado: (2011)

Angiogenin Upregulation Independently Predicts Unfavorable Overall Survival in Proneural Subtype of Glioblastoma
por: Hu, Ji-liang, et al.
Publicado: (2019)

LonP1 Drives Proneural Mesenchymal Transition in IDH1-R132H Diffuse Glioma
por: Douglas, Christopher, et al.
Publicado: (2023)

Multi-Omics Analysis of Glioblastoma and Glioblastoma Cell Line: Molecular Insights Into the Functional Role of GPR56 and TG2 in Mesenchymal Transition
por: Ganesh, Raksha A., et al.
Publicado: (2022)

Substrate stiffness effect on molecular crosstalk of epithelial-mesenchymal transition mediators of human glioblastoma cells
por: Basilico, Bernadette, et al.
Publicado: (2022)

Increased LGALS3 expression independently predicts shorter overall survival in patients with the proneural subtype of glioblastoma
por: He, Xia, et al.
Publicado: (2019)

SPI1-mediated MIR222HG transcription promotes proneural-to-mesenchymal transition of glioma stem cells and immunosuppressive polarization of macrophages
por: Fan, Yang, et al.
Publicado: (2023)

lncRNA PRADX is a Mesenchymal Glioblastoma Biomarker for Cellular Metabolism Targeted Therapy
por: Xu, Can, et al.
Publicado: (2022)

The proneural gene ASCL1 governs the transcriptional subgroup affiliation in glioblastoma stem cells by directly repressing the mesenchymal gene NDRG1
por: Narayanan, Ashwin, et al.
Publicado: (2018)

Heterogeneity of Amino Acid Profiles of Proneural and Mesenchymal Brain-Tumor Initiating Cells
por: Seliger, Corinna, et al.
Publicado: (2023)

FoxM1 drives ADAM17/EGFR activation loop to promote mesenchymal transition in glioblastoma
por: Zhang, Chunli, et al.
Publicado: (2018)

Targeting SREBP-1-Mediated Lipogenesis as Potential Strategies for Cancer
por: Zhao, Qiushi, et al.
Publicado: (2022)

BYSL Promotes Glioblastoma Cell Migration, Invasion, and Mesenchymal Transition Through the GSK-3β/β-Catenin Signaling Pathway
por: Sha, Zhuang, et al.
Publicado: (2020)

Dihydropyrimidinase-related protein 5 controls glioblastoma stem cell characteristics as a biomarker of proneural-subtype glioblastoma stem cells
por: Park, Min Gi, et al.
Publicado: (2020)

Angiocrine extracellular vesicles impose mesenchymal reprogramming upon proneural glioma stem cells
por: Adnani, Lata, et al.
Publicado: (2022)

Niche deconvolution of the glioblastoma proteome reveals a distinct infiltrative phenotype within the proneural transcriptomic subgroup
por: Lam, K. H. Brian, et al.
Publicado: (2022)

Dual Role of Integrin Alpha-6 in Glioblastoma: Supporting Stemness in Proneural Stem-Like Cells While Inducing Radioresistance in Mesenchymal Stem-Like Cells
por: Stanzani, Elisabetta, et al.
Publicado: (2021)

TGF-β1 promotes human breast cancer angiogenesis and malignant behavior by regulating endothelial-mesenchymal transition
por: Li, Zi-Xiong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_s7vi05ius7fhk4pf6g848o87eo