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Using a new HSPC senescence model in vitro to explore the mechanism of cellular memory in aging HSPCs

BACKGROUND: Age-associated changes attenuate human blood system functionality through the aging of hematopoietic stem and progenitor cells (HSPCs), manifested in human populations an increase in myeloproliferative disease and even leukemia; therefore, study on HSPC senescence bears great significanc...

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Detalles Bibliográficos
Autores principales: Dong, Yongpin, Guo, Chunni, Zhou, Wuxiong, Li, Wenfang, Zhang, Lina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351417/
https://www.ncbi.nlm.nih.gov/pubmed/34365970
http://dx.doi.org/10.1186/s13287-021-02455-x