Intra-Tumoral Activation of Endosomal TLR Pathways Reveals a Distinct Role for TLR3 Agonist Dependent Type-1 Interferons in Shaping the Tumor Immune Microenvironment

Toll-like receptor (TLR) agonists have received considerable attention as therapeutic targets for cancer immunotherapy owing to their ability to convert immunosuppressive tumor microenvironments towards a more T-cell inflamed phenotype. However, TLRs differ in their cell expression profiles and intr...

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Detalles Bibliográficos
Autores principales: Thomas, Graham, Micci, Luca, Yang, Wenjing, Katakowski, Joseph, Oderup, Cecilia, Sundar, Purnima, Wang, Xiao, Geles, Kenneth G., Potluri, Shobha, Salek-Ardakani, Shahram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351420/
https://www.ncbi.nlm.nih.gov/pubmed/34381732
http://dx.doi.org/10.3389/fonc.2021.711673

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351420/
https://www.ncbi.nlm.nih.gov/pubmed/34381732
http://dx.doi.org/10.3389/fonc.2021.711673

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