Cargando…

Intra-Tumoral Activation of Endosomal TLR Pathways Reveals a Distinct Role for TLR3 Agonist Dependent Type-1 Interferons in Shaping the Tumor Immune Microenvironment

Toll-like receptor (TLR) agonists have received considerable attention as therapeutic targets for cancer immunotherapy owing to their ability to convert immunosuppressive tumor microenvironments towards a more T-cell inflamed phenotype. However, TLRs differ in their cell expression profiles and intr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thomas, Graham, Micci, Luca, Yang, Wenjing, Katakowski, Joseph, Oderup, Cecilia, Sundar, Purnima, Wang, Xiao, Geles, Kenneth G., Potluri, Shobha, Salek-Ardakani, Shahram
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351420/ https://www.ncbi.nlm.nih.gov/pubmed/34381732 http://dx.doi.org/10.3389/fonc.2021.711673

Ejemplares similares

Combinatorial immunotherapy induces tumor-infiltrating CD8(+) T cells with distinct functional, migratory, and stem-like properties
por: Van Braeckel-Budimir, Natalija, et al.
Publicado: (2021)

Liposomal TLR9 Agonist Combined with TLR2 Agonist-Fused Antigen Can Modulate Tumor Microenvironment through Dendritic Cells
por: Shen, Kuan-Yin, et al.
Publicado: (2020)

The Latest Approach of Immunotherapy with Endosomal TLR Agonists Improving NK Cell Function: An Overview
por: Veneziani, Irene, et al.
Publicado: (2022)

Endosomal TLR3, TLR7, and TLR8 control neuronal morphology through different transcriptional programs
por: Hung, Yun-Fen, et al.
Publicado: (2018)

Synergistic Induction of Interferon α through TLR-3 and TLR-9 Agonists Identifies CD21 as Interferon α Receptor for the B Cell Response
por: Kim, Dhohyung, et al.
Publicado: (2013)

Differential Depletion of Bone Marrow Resident B-ALL after Systemic Administration of Endosomal TLR Agonists
por: Jo, Sumin, et al.
Publicado: (2020)

Circulating nano-particulate TLR9 agonist scouts out tumor microenvironment to release immunogenic dead tumor cells
por: Kitahata, Yuji, et al.
Publicado: (2016)

Different dimerisation mode for TLR4 upon endosomal acidification?
por: Gangloff, Monique
Publicado: (2012)

Comparison of human B cell activation by TLR7 and TLR9 agonists
por: Hanten, John A, et al.
Publicado: (2008)

Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists
por: Cheng, Kui, et al.
Publicado: (2015)

Trial Watch: experimental TLR7/TLR8 agonists for oncological indications
por: Frega, Giorgio, et al.
Publicado: (2020)

Deoxyguanosine is a TLR7 agonist
por: Davenne, Tamara, et al.
Publicado: (2019)

Beneficial modulation of the tumor microenvironment and generation of anti-tumor responses by TLR9 agonist lefitolimod alone and in combination with checkpoint inhibitors
por: Kapp, Kerstin, et al.
Publicado: (2019)

NOD2 Agonist Promotes the Production of Inflammatory Cytokines in VSMC in Synergy with TLR2 and TLR4 Agonists
por: Sun, Jinghua, et al.
Publicado: (2012)

An In Situ Autologous Tumor Vaccination with Combined Radiation Therapy and TLR9 Agonist Therapy
por: Zhang, Huagang, et al.
Publicado: (2012)

The Processed Amino-Terminal Fragment of Human TLR7 Acts as a Chaperone To Direct Human TLR7 into Endosomes
por: Hipp, Madeleine M., et al.
Publicado: (2015)

TLR2 and endosomal TLR-mediated secretion of IL-10 and immune suppression in response to phagosome-confined Listeria monocytogenes
por: Nguyen, Brittney N., et al.
Publicado: (2020)

Overexpression of TLR2 and TLR9 on monocyte subsets of active rheumatoid arthritis patients contributes to enhance responsiveness to TLR agonists
por: Lacerte, Patricia, et al.
Publicado: (2016)

Innate Immune Receptors in Human Airway Smooth Muscle Cells: Activation by TLR1/2, TLR3, TLR4, TLR7 and NOD1 Agonists
por: Månsson Kvarnhammar, Anne, et al.
Publicado: (2013)

A Therapeutic Whole-Tumor-Cell Vaccine Covalently Conjugated with a TLR7 Agonist
por: Chi, Huju, et al.
Publicado: (2022)

TLR5 agonists enhance anti-tumor immunity and overcome resistance to immune checkpoint therapy
por: Gonzalez, Caleb, et al.
Publicado: (2023)

TLR3 and TLR9 Agonists Improve Postexposure Vaccination Efficacy of Live Smallpox Vaccines
por: Israely, Tomer, et al.
Publicado: (2014)

Cytokine Effect of TLR3, TLR4, and TLR7 Agonists Alone or Associated with Leishmania infantum Antigen on Blood from Dogs
por: Martínez-Orellana, Pamela, et al.
Publicado: (2018)

Differential Response of Gestational Tissues to TLR3 Viral Priming Prior to Exposure to Bacterial TLR2 and TLR2/6 Agonists
por: Rasheed, Zahirrah B. M., et al.
Publicado: (2020)

Targeted delivery of TLR3 agonist to tumor cells with single chain antibody fragment-conjugated nanoparticles induces type I-interferon response and apoptosis
por: Schau, Isabell, et al.
Publicado: (2019)

Cell based assay identifies TLR2 and TLR4 stimulating impurities in Interferon beta
por: Haile, Lydia Asrat, et al.
Publicado: (2017)

Contribution of TLR4 to colorectal tumor microenvironment, etiology and prognosis
por: Crame, Elise E., et al.
Publicado: (2022)

TLR sorting by Rab11 endosomes maintains intestinal epithelial-microbial homeostasis
por: Yu, Shiyan, et al.
Publicado: (2014)

The combination of TLR2 and TLR4 agonists promotes the immunogenicity of dendritic cell/cancer cell fusions
por: Koido, Shigeo, et al.
Publicado: (2013)

Development of N-Acetylated Dipalmitoyl-S-Glyceryl Cysteine Analogs as Efficient TLR2/TLR6 Agonists
por: Zhou, Yang, et al.
Publicado: (2019)

Molecular dynamics simulations reveal the selectivity mechanism of structurally similar agonists to TLR7 and TLR8
por: Wang, Xiaoyu, et al.
Publicado: (2022)

Intratumoral immune activation with TLR4 agonist synergizes with effector T cells to eradicate established murine tumors
por: Albershardt, Tina C., et al.
Publicado: (2020)

Increased translocation of antigens to endosomes and TLR4 mediated endosomal recruitment of TAP contribute to nicotine augmented cross-presentation
por: Wang, Yan Yan, et al.
Publicado: (2016)

The TLR9 agonist MGN1703 triggers a potent type I interferon response in the sigmoid colon
por: Krarup, Astrid Raaby, et al.
Publicado: (2017)

Selected TLR7/8 agonist and type I interferon (IFN-α) cooperatively redefine the microglia transcriptome
por: Khatun, Mst Reshma, et al.
Publicado: (2019)

Dendritic Cell Vaccination in Conjunction with a TLR Agonist Polarizes Interferon Immune Responses in Malignant Glioma Patients
por: Everson, Richard G., et al.
Publicado: (2023)

Microbial TLR Agonists and Humoral Immunopathogenesis in HIV Disease
por: Yu, Xiaocong, et al.
Publicado: (2013)

Trial watch: TLR3 agonists in cancer therapy
por: Le Naour, Julie, et al.
Publicado: (2020)

OMV Vaccines and the Role of TLR Agonists in Immune Response
por: Mancini, Francesca, et al.
Publicado: (2020)

Formulated Phospholipids as Non-Canonical TLR4 Agonists
por: Liang, Hong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_q50t08g657l4nqfpo46vldo2j5