Cargando…

SIRT1/PGC-1α/PPAR-γ Correlate With Hypoxia-Induced Chemoresistance in Non-Small Cell Lung Cancer

Resistance is the major cause of treatment failure and disease progression in non-small cell lung cancer (NSCLC). There is evidence that hypoxia is a key microenvironmental stress associated with resistance to cisplatin, epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Rui, Luo, Xin, Ye, Xuan, Li, Huan, Liu, Hongyue, Du, Qiong, Zhai, Qing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351465/ https://www.ncbi.nlm.nih.gov/pubmed/34381712 http://dx.doi.org/10.3389/fonc.2021.682762

Ejemplares similares

PPARγ and PGC-1α as Therapeutic Targets in Parkinson’s
por: Corona, Juan Carlos, et al.
Publicado: (2014)

ATGL-Catalyzed Lipolysis Regulates SIRT1 to Control PGC-1α/PPAR-α Signaling
por: Khan, Salmaan Ahmed, et al.
Publicado: (2015)

Resveratrol enhances HBV replication through activating Sirt1-PGC-1α-PPARα pathway
por: Shi, Yixian, et al.
Publicado: (2016)

Stemness of Normal and Cancer Cells: The Influence of Methionine Needs and SIRT1/PGC-1α/PPAR-α Players
por: Siblini, Youssef, et al.
Publicado: (2022)

QKI 6 ameliorates CIRI through promoting synthesis of triglyceride in neuron and inhibiting neuronal apoptosis associated with SIRT1‐PPARγ‐PGC‐1α axis
por: Liu, Rui, et al.
Publicado: (2021)

Trans-Cinnamaldehyde Alleviates Amyloid-Beta Pathogenesis via the SIRT1-PGC1α-PPARγ Pathway in 5XFAD Transgenic Mice
por: Do, Jimin, et al.
Publicado: (2020)

PGC-1α Protects against Hepatic Ischemia Reperfusion Injury by Activating PPARα and PPARγ and Regulating ROS Production
por: Wang, Chaoqun, et al.
Publicado: (2021)

Lack of Genetic Associations of PPAR-γ and PGC-1α with Alzheimer's Disease and Parkinson's Disease with Dementia
por: Shibata, Nobuto, et al.
Publicado: (2013)

Resveratrol protects mitochondrial quantity by activating SIRT1/PGC‐1α expression during ovarian hypoxia
por: Nishigaki, Akemi, et al.
Publicado: (2020)

MAR1 suppresses inflammatory response in LPS-induced RAW 264.7 macrophages and human primary peripheral blood mononuclear cells via the SIRT1/PGC-1α/PPAR-γ pathway
por: Wang, Wei, et al.
Publicado: (2021)

SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop associated with senescence
por: Han, Limin, et al.
Publicado: (2010)

Huoxue Huatan Decoction Ameliorates Myocardial Ischemia/Reperfusion Injury in Hyperlipidemic Rats via PGC-1α–PPARα and PGC-1α–NRF1–mtTFA Pathways
por: Lin, Fei, et al.
Publicado: (2020)

Astrocytes Protect Neurons from Aβ(1-42) Peptide-Induced Neurotoxicity Increasing TFAM and PGC-1 and Decreasing PPAR-γ and SIRT-1
por: Aguirre-Rueda, Diana, et al.
Publicado: (2015)

Deciphering the Dichotomous Effects of PGC-1α on Tumorigenesis and Metastasis
por: Gravel, Simon-Pierre
Publicado: (2018)

CRTC1/MAML2 directs a PGC-1α-IGF-1 circuit that confers vulnerability to PPARγ inhibition
por: Musicant, Adele M., et al.
Publicado: (2021)

Nobiletin Attenuates Pathological Cardiac Remodeling after Myocardial Infarction via Activating PPARγ and PGC1α
por: Zhou, Yufei, et al.
Publicado: (2021)

Cholecystokinin Octapeptide Promotes ANP Secretion through Activation of NOX4–PGC-1α–PPARα/PPARγ Signaling in Isolated Beating Rat Atria
por: Han, Zhuo-na, et al.
Publicado: (2022)

Catalpol Ameliorates Insulin Sensitivity and Mitochondrial Respiration in Skeletal Muscle of Type-2 Diabetic Mice Through Insulin Signaling Pathway and AMPK/SIRT1/PGC-1α/PPAR-γ Activation
por: Yap, Kah Heng, et al.
Publicado: (2020)

Dynamic Partnership between TFIIH, PGC-1α and SIRT1 Is Impaired in Trichothiodystrophy
por: Traboulsi, Hussein, et al.
Publicado: (2014)

PXR Suppresses PPARα-Dependent HMGCS2 Gene Transcription by Inhibiting the Interaction between PPARα and PGC1α
por: Shizu, Ryota, et al.
Publicado: (2021)

Maternal obesity inhibits placental angiogenesis by down-regulating the SIRT1/PGC-1α pathway
por: Peng, Huilin, et al.
Publicado: (2022)

Dual Role of Phenyl Amides from Hempseed on BACE 1, PPARγ, and PGC-1α in N2a-APP Cells
por: Rea Martinez, Julio, et al.
Publicado: (2021)

Nicotinamide Inhibits Glycolysis of HL-60 Cells by Modulating Sirtuin 1 (SIRT1)/Peroxisome Proliferator-Activated Receptor γ Coactivator 1α (PGC-1α)/Hypoxia-Inducible Factor-2α (HIF2α) Signaling Pathway
por: Liu, Miao, et al.
Publicado: (2020)

Aerobic exercise combined with chlorogenic acid exerts neuroprotective effects and reverses cognitive decline in Alzheimer’s disease model mice (APP/PS1) via the SIRT1/ /PGC-1α/PPARγ signaling pathway
por: Shi, Dan, et al.
Publicado: (2023)

MicroRNA-130a can inhibit hepatitis B virus replication via targeting PGC1α and PPARγ
por: Huang, Jyun-Yuan, et al.
Publicado: (2015)

PGC1α induced by reactive oxygen species contributes to chemoresistance of ovarian cancer cells
por: Kim, Boyun, et al.
Publicado: (2017)

Electroacupuncture Upregulates SIRT1-Dependent PGC-1α Expression in SAMP8 Mice
por: Dong, Weiguo, et al.
Publicado: (2015)

Effects of Resveratrol and SIRT1 on PGC-1α Activity and Mitochondrial Biogenesis: A Reevaluation
por: Higashida, Kazuhiko, et al.
Publicado: (2013)

Role of SIRT1/PGC-1α in mitochondrial oxidative stress in autistic spectrum disorder
por: Bu, Xiaosong, et al.
Publicado: (2017)

Myricetin improves endurance capacity and mitochondrial density by activating SIRT1 and PGC-1α
por: Jung, Hoe-Yune, et al.
Publicado: (2017)

Isosteviol sodium protects the cardiomyocyte response associated with the SIRT1/PGC‐1α pathway
por: Mei, Ying, et al.
Publicado: (2020)

Nicotinamide mononucleotide attenuates glucocorticoid-induced osteogenic inhibition by regulating the SIRT1/PGC-1α signaling pathway
por: Huang, Rui-Xiong, et al.
Publicado: (2020)

Neobavaisoflavone Induces Bilirubin Metabolizing Enzyme UGT1A1 via PPARα and PPARγ
por: Zhu, Ya-Di, et al.
Publicado: (2021)

Role of SIRT1 in Chemoresistant Leukemia
por: Fajardo-Orduña, Guadalupe Rosario, et al.
Publicado: (2023)

∆nFGF1 Protects β-Cells against High Glucose-Induced Apoptosis via the AMPK/SIRT1/PGC-1α Axis
por: Chen, Qiong, et al.
Publicado: (2022)

Palmitate-induced Regulation of PPARγ via PGC1α: a Mechanism for Lipid Accumulation in the Liver in Nonalcoholic Fatty Liver Disease
por: Maruyama, Hitoshi, et al.
Publicado: (2016)

PGC-1α Promotes Ureagenesis in Mouse Periportal Hepatocytes through SIRT3 and SIRT5 in Response to Glucagon
por: Li, Lulu, et al.
Publicado: (2016)

Salvianolic Acid B Improves Mitochondrial Function in 3T3-L1 Adipocytes Through a Pathway Involving PPARγ Coactivator-1α (PGC-1α)
por: Pan, Yanyun, et al.
Publicado: (2018)

PERM1 regulates genes involved in fatty acid metabolism in the heart by interacting with PPARα and PGC-1α
por: Huang, Chun-yang, et al.
Publicado: (2022)

Basolateral Amygdala SIRT1/PGC-1α Mitochondrial Biogenesis Pathway Mediates Morphine Withdrawal-Associated Anxiety in Mice
por: Yin, Fangyuan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_o8qijq0t0ijhhls3hv9phu3k8d