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Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons

The dependence of neurons on microtubule-based motors for the movement of lysosomes over long distances raises questions about adaptations that allow neurons to meet these demands. Recently, JIP3/MAPK8IP3, a neuronally enriched putative adaptor between lysosomes and motors, was identified as a criti...

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Detalles Bibliográficos
Autores principales: Gowrishankar, Swetha, Lyons, Lila, Rafiq, Nisha Mohd, Roczniak-Ferguson, Agnes, De Camilli, Pietro, Ferguson, Shawn M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351540/
https://www.ncbi.nlm.nih.gov/pubmed/33788575
http://dx.doi.org/10.1091/mbc.E20-06-0382