Truncation of the otoferlin transmembrane domain alters the development of hair cells and reduces membrane docking

Release of neurotransmitter from sensory hair cells is regulated by otoferlin. Despite the importance of otoferlin in the auditory and vestibular pathways, the functional contributions of the domains of the protein have not been fully characterized. Using a zebrafish model, we investigated a mutant...

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Detalles Bibliográficos
Autores principales: Manchanda, Aayushi, Bonventre, Josephine A., Bugel, Sean M., Chatterjee, Paroma, Tanguay, Robyn, Johnson, Colin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351550/
https://www.ncbi.nlm.nih.gov/pubmed/33979209
http://dx.doi.org/10.1091/mbc.E20-10-0657

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351550/
https://www.ncbi.nlm.nih.gov/pubmed/33979209
http://dx.doi.org/10.1091/mbc.E20-10-0657

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