Design of Novel Amphipathic α-Helical Antimicrobial Peptides with No Toxicity as Therapeutics against the Antibiotic-Resistant Gram-Negative Bacterial Pathogen, Acinetobacter Baumannii

We designed de novo and synthesized two series of five 26-residue amphipathic α-helical cationic antimicrobial peptides (AMPs) with five or six positively charged residues (D-Lys, L-Dab (2,4-diaminobutyric acid) or L-Dap (2,3-diaminopropionic acid)) on the polar face where all other residues are in...

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Detalles Bibliográficos
Autores principales: Mant, Colin T, Jiang, Ziqing, Gera, Lajos, Davis, Tim, Hodges, Robert S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351594/
https://www.ncbi.nlm.nih.gov/pubmed/34377965

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351594/
https://www.ncbi.nlm.nih.gov/pubmed/34377965

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