Insight into purification of monoclonal antibodies in industrial columns via studies of Protein A binding capacity by in situ ATR-FTIR spectroscopy

Therapeutic monoclonal antibodies (mAbs) are effective treatments for a range of cancers and other serious diseases, however mAb treatments cost on average ∼$100 000 per year per patient, limiting their use. Currently, industry favours Protein A affinity chromatography (PrAc) as the key step in down...

Descripción completa

Detalles Bibliográficos
Autores principales: Beattie, James W., Rowland-Jones, Ruth C., Farys, Monika, Tran, Richard, Kazarian, Sergei G., Byrne, Bernadette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351638/
https://www.ncbi.nlm.nih.gov/pubmed/34296229
http://dx.doi.org/10.1039/d1an00985k

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351638/
https://www.ncbi.nlm.nih.gov/pubmed/34296229
http://dx.doi.org/10.1039/d1an00985k

Ejemplares similares