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Cell adaptation to aneuploidy by the environmental stress response dampens induction of the cytosolic unfolded-protein response
Aneuploid yeast cells are in a chronic state of proteotoxicity, yet do not constitutively induce the cytosolic unfolded protein response, or heat shock response (HSR) by heat shock factor 1 (Hsf1). Here, we demonstrate that an active environmental stress response (ESR), a hallmark of aneuploidy acro...
Autores principales: | Kane, Andrew J., Brennan, Christopher M., Xu, Acer E., Solís, Eric J., Terhorst, Allegra, Denic, Vladimir, Amon, Angelika |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351746/ https://www.ncbi.nlm.nih.gov/pubmed/34191542 http://dx.doi.org/10.1091/mbc.E21-03-0104 |
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