SPNS2 enables T cell egress from lymph nodes during an immune response

T cell expression of sphingosine 1-phosphate (S1P) receptor 1 (S1PR1) enables T cell exit from lymph nodes (LNs) into lymph, while endothelial S1PR1 expression regulates vascular permeability. Drugs targeting S1PR1 treat autoimmune disease by trapping pathogenic T cells within LNs, but they have adv...

Descripción completa

Detalles Bibliográficos
Autores principales: Okuniewska, Martyna, Fang, Victoria, Baeyens, Audrey, Raghavan, Varsha, Lee, June-Yong, Littman, Dan R., Schwab, Susan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351797/
https://www.ncbi.nlm.nih.gov/pubmed/34260944
http://dx.doi.org/10.1016/j.celrep.2021.109368

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351797/
https://www.ncbi.nlm.nih.gov/pubmed/34260944
http://dx.doi.org/10.1016/j.celrep.2021.109368

Ejemplares similares