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SPNS2 enables T cell egress from lymph nodes during an immune response

T cell expression of sphingosine 1-phosphate (S1P) receptor 1 (S1PR1) enables T cell exit from lymph nodes (LNs) into lymph, while endothelial S1PR1 expression regulates vascular permeability. Drugs targeting S1PR1 treat autoimmune disease by trapping pathogenic T cells within LNs, but they have adv...

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Detalles Bibliográficos
Autores principales:	Okuniewska, Martyna, Fang, Victoria, Baeyens, Audrey, Raghavan, Varsha, Lee, June-Yong, Littman, Dan R., Schwab, Susan R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351797/ https://www.ncbi.nlm.nih.gov/pubmed/34260944 http://dx.doi.org/10.1016/j.celrep.2021.109368

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