Niche Laminin and IGF-1 Additively Coordinate the Maintenance of Oct-4 Through CD49f/IGF-1R-Hif-2α Feedforward Loop in Mouse Germline Stem Cells

The mechanism on how extracellular matrix (ECM) cooperates with niche growth factors and oxygen tension to regulate the self-renewal of embryonic germline stem cells (GSCs) still remains unclear. Lacking of an appropriate in vitro cell model dramatically hinders the progress. Herein, using a serum-f...

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Detalles Bibliográficos
Autores principales: Au, Heng-Kien, Peng, Syue-Wei, Guo, Chin-Lin, Lin, Chien-Chia, Wang, Yi-Lin, Kuo, Yung-Che, Law, Tsz-Yau, Ho, Hong-Nerng, Ling, Thai-Yen, Huang, Yen-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351907/
https://www.ncbi.nlm.nih.gov/pubmed/34381769
http://dx.doi.org/10.3389/fcell.2021.646644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351907/
https://www.ncbi.nlm.nih.gov/pubmed/34381769
http://dx.doi.org/10.3389/fcell.2021.646644

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