Cargando…
Mathematical modeling of N-803 treatment in SIV-infected non-human primates
Immunomodulatory drugs could contribute to a functional cure for Human Immunodeficiency Virus (HIV). Interleukin-15 (IL-15) promotes expansion and activation of CD8(+) T cell and natural killer (NK) cell populations. In one study, an IL-15 superagonist, N-803, suppressed Simian Immunodeficiency Viru...
Autores principales: | Cody, Jonathan W., Ellis-Connell, Amy L., O’Connor, Shelby L., Pienaar, Elsje |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351941/ https://www.ncbi.nlm.nih.gov/pubmed/34319980 http://dx.doi.org/10.1371/journal.pcbi.1009204 |
Ejemplares similares
-
Mathematical modeling indicates that regulatory inhibition of CD8(+) T cell cytotoxicity can limit efficacy of IL-15 immunotherapy in cases of high pre-treatment SIV viral load
por: Cody, Jonathan W., et al.
Publicado: (2023) -
Therapeutic Potential of IL-15 and N-803 in HIV/SIV Infection
por: Harwood, Olivia, et al.
Publicado: (2021) -
Monkeying around with MAIT Cells: Studying the Role of MAIT Cells in SIV and Mtb Co-Infection
por: Moriarty, Ryan V., et al.
Publicado: (2021) -
Integrating Non-human Primate, Human, and Mathematical Studies to Determine the Influence of BCG Timing on H56 Vaccine Outcomes
por: Joslyn, Louis R., et al.
Publicado: (2018) -
MAIT cells are functionally impaired in a Mauritian cynomolgus macaque model of SIV and Mtb co-infection
por: Ellis, Amy L., et al.
Publicado: (2020)