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Targeting Mycobacterium tuberculosis response to environmental cues for the development of effective antitubercular drugs
Sensing and response to environmental cues, such as pH and chloride (Cl(−)), is critical in enabling Mycobacterium tuberculosis (Mtb) colonization of its host. Utilizing a fluorescent reporter Mtb strain in a chemical screen, we have identified compounds that dysregulate Mtb response to high Cl(−) l...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8351955/ https://www.ncbi.nlm.nih.gov/pubmed/34319985 http://dx.doi.org/10.1371/journal.pbio.3001355 |