Investigating Crosstalk Among PTMs Provides Novel Insight Into the Structural Basis Underlying the Differential Effects of Nt17 PTMs on Mutant Httex1 Aggregation

Post-translational modifications (PTMs) within the first 17 amino acids (Nt17) of the Huntingtin protein (Htt) have been shown to inhibit the aggregation and attenuate the toxicity of mutant Htt proteins in vitro and in various models of Huntington’s disease. Here, we expand on these studies by inve...

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Detalles Bibliográficos
Autores principales: Chiki, Anass, Zhang, Zhidian, Rajasekhar, Kolla, Abriata, Luciano A., Rostami, Iman, Krapp, Lucien F., Boudeffa, Driss, Dal Peraro, Matteo, Lashuel, Hilal A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352439/
https://www.ncbi.nlm.nih.gov/pubmed/34381813
http://dx.doi.org/10.3389/fmolb.2021.686086

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352439/
https://www.ncbi.nlm.nih.gov/pubmed/34381813
http://dx.doi.org/10.3389/fmolb.2021.686086

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