Cargando…

Investigating Crosstalk Among PTMs Provides Novel Insight Into the Structural Basis Underlying the Differential Effects of Nt17 PTMs on Mutant Httex1 Aggregation

Post-translational modifications (PTMs) within the first 17 amino acids (Nt17) of the Huntingtin protein (Htt) have been shown to inhibit the aggregation and attenuate the toxicity of mutant Htt proteins in vitro and in various models of Huntington’s disease. Here, we expand on these studies by inve...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chiki, Anass, Zhang, Zhidian, Rajasekhar, Kolla, Abriata, Luciano A., Rostami, Iman, Krapp, Lucien F., Boudeffa, Driss, Dal Peraro, Matteo, Lashuel, Hilal A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352439/ https://www.ncbi.nlm.nih.gov/pubmed/34381813 http://dx.doi.org/10.3389/fmolb.2021.686086

Ejemplares similares

Site‐Specific Phosphorylation of Huntingtin Exon 1 Recombinant Proteins Enabled by the Discovery of Novel Kinases
por: Chiki, Anass, et al.
Publicado: (2020)

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations
por: Hornbeck, Peter V., et al.
Publicado: (2014)

Proteomic Analysis of Histone Variants and Their PTMs: Strategies and Pitfalls
por: El Kennani, Sara, et al.
Publicado: (2018)

PPARγ in Atherosclerotic Endothelial Dysfunction: Regulatory Compounds and PTMs
por: Luan, Jinwen, et al.
Publicado: (2023)

Two distinct modes for propagation of histone PTMs across the cell cycle
por: Alabert, Constance, et al.
Publicado: (2015)

Thiol-based Oxidative Posttranslational Modifications (OxiPTMs) of Plant Proteins
por: Corpas, Francisco J, et al.
Publicado: (2022)

Antioxidant Systems are Regulated by Nitric Oxide-Mediated Post-translational Modifications (NO-PTMs)
por: Begara-Morales, Juan C., et al.
Publicado: (2016)

Editorial: Targeting Protein Post-Translational Modifications (PTMs) for Diagnosis and Treatment of Sepsis
por: Chang, Panpan, et al.
Publicado: (2022)

Role of Host-Mediated Post-Translational Modifications (PTMs) in RNA Virus Pathogenesis
por: Kumar, Ramesh, et al.
Publicado: (2020)

PTMs in Conversation: Activity and Function of Deubiquitinating Enzymes Regulated via Post-Translational Modifications
por: Kessler, Benedikt M., et al.
Publicado: (2011)

Identification of ubiquitin/ubiquitin-like protein modification from tandem mass spectra with various PTMs
por: Kang, Chiyong, et al.
Publicado: (2011)

HiLight-PTM: an online application to aid matching peptide pairs with isotopically labelled PTMs
por: Whitwell, Harry J, et al.
Publicado: (2019)

Analysis of STAT3 post-translational modifications (PTMs) in human prostate cancer with different Gleason Score
por: Cocchiola, Rossana, et al.
Publicado: (2017)

Ubiquitin-Like Post-Translational Modifications (Ubl-PTMs): Small Peptides with Huge Impact in Liver Fibrosis
por: Lachiondo-Ortega, Sofia, et al.
Publicado: (2019)

Common Post-translational Modifications (PTMs) of Proteins: Analysis by Up-to-Date Analytical Techniques with an Emphasis on Barley
por: Bobalova, Janette, et al.
Publicado: (2023)

Unbiased Phosphoproteome Mining Reveals New Functional Sites of Metabolite-Derived PTMs Involved in MASLD Development
por: Moltó, Eduardo, et al.
Publicado: (2023)

Mass spectrometry analysis of transthyretin (TTR) post-translational modifications (PTMs) in hereditary ATTR: a case-control Spanish experience
por: Vilà-Rico, Marta, et al.
Publicado: (2015)

PeSTo: parameter-free geometric deep learning for accurate prediction of protein binding interfaces
por: Krapp, Lucien F., et al.
Publicado: (2023)

Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy
por: Reif, Andreas, et al.
Publicado: (2018)

XPS and structural studies of Fe(3)O(4)-PTMS-NAS@Cu as a novel magnetic natural asphalt base network and recoverable nanocatalyst for the synthesis of biaryl compounds
por: Kohzadi, Homa, et al.
Publicado: (2021)

A simple, versatile and robust centrifugation‐based filtration protocol for the isolation and quantification of α‐synuclein monomers, oligomers and fibrils: Towards improving experimental reproducibility in α‐synuclein research
por: Kumar, Senthil T., et al.
Publicado: (2020)

Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau
por: Ait-Bouziad, Nadine, et al.
Publicado: (2020)

Assessing the potential of atomistic molecular dynamics simulations to probe reversible protein-protein recognition and binding
por: Abriata, Luciano A., et al.
Publicado: (2015)

Assessment of transferable forcefields for protein simulations attests improved description of disordered states and secondary structure propensities, and hints at multi-protein systems as the next challenge for optimization
por: Abriata, Luciano A., et al.
Publicado: (2021)

N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting
por: DeGuire, Sean M., et al.
Publicado: (2018)

Artificial intelligence–coupled plasmonic infrared sensor for detection of structural protein biomarkers in neurodegenerative diseases
por: Kavungal, Deepthy, et al.
Publicado: (2023)

Erratum to: Detection and sequence/structure mapping of biophysical constraints to protein variation in saturated mutational libraries and protein sequence alignments with a dedicated server
por: Abriata, Luciano A., et al.
Publicado: (2016)

How Structural and Physicochemical Determinants Shape Sequence Constraints in a Functional Enzyme
por: Abriata, Luciano A., et al.
Publicado: (2015)

Detection and sequence/structure mapping of biophysical constraints to protein variation in saturated mutational libraries and protein sequence alignments with a dedicated server
por: Abriata, Luciano A., et al.
Publicado: (2016)

Site‐Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding
por: Haj‐Yahya, Mahmood, et al.
Publicado: (2020)

The Role of Post-translational Modifications on the Energy Landscape of Huntingtin N-Terminus
por: Yalinca, Havva, et al.
Publicado: (2019)

Editorial: Multiscale Modeling From Macromolecules to Cell: Opportunities and Challenges of Biomolecular Simulations
por: Palermo, Giulia, et al.
Publicado: (2020)

Structural, physicochemical and dynamic features conserved within the aerolysin pore-forming toxin family
por: Cirauqui, Nuria, et al.
Publicado: (2017)

Exosome-Mediated Crosstalk Between Tumor and Tumor-Associated Macrophages
por: Chen, Qi, et al.
Publicado: (2021)

Crosstalk between ferroptosis and steroid hormone signaling in gynecologic cancers
por: Lai, Wen, et al.
Publicado: (2023)

Crosstalk Between Type VI Secretion System and Mobile Genetic Elements
por: Peñil-Celis, Arancha, et al.
Publicado: (2019)

Temperature as a modulator of allosteric motions and crosstalk in mesophilic and thermophilic enzymes
por: Knight, Alexa L., et al.
Publicado: (2023)

An experiment-informed signal transduction model for the role of the Staphylococcus aureus MecR1 protein in β-lactam resistance
por: Belluzo, Bruno S., et al.
Publicado: (2019)

Understanding the Holobiont: Crosstalk Between Gut Microbiota and Mitochondria During Long Exercise in Horse
por: Mach, Núria, et al.
Publicado: (2021)

Immune Crosstalk Between Lymph Nodes and Breast Carcinomas, With a Focus on B Cells
por: Alberts, Elena, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_q5qrh9t31n2hcjess8s30mgvho