Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs

IFN-I and IFN-III immunity in the nasal mucosa is poorly characterized during SARS-CoV-2 infection. We analyze the nasal IFN-I/III signature, namely the expression of ISGF-3–dependent IFN-stimulated genes, in mildly symptomatic COVID-19 patients and show its correlation with serum IFN-α(2) levels, w...

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Detalles Bibliográficos
Autores principales: Lopez, Jonathan, Mommert, Marine, Mouton, William, Pizzorno, Andrés, Brengel-Pesce, Karen, Mezidi, Mehdi, Villard, Marine, Lina, Bruno, Richard, Jean-Christophe, Fassier, Jean-Baptiste, Cheynet, Valérie, Padey, Blandine, Duliere, Victoria, Julien, Thomas, Paul, Stéphane, Bastard, Paul, Belot, Alexandre, Bal, Antonin, Casanova, Jean-Laurent, Rosa-Calatrava, Manuel, Morfin, Florence, Walzer, Thierry, Trouillet-Assant, Sophie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352718/
https://www.ncbi.nlm.nih.gov/pubmed/34357402
http://dx.doi.org/10.1084/jem.20211211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352718/
https://www.ncbi.nlm.nih.gov/pubmed/34357402
http://dx.doi.org/10.1084/jem.20211211

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