A KLK4 proteinase substrate capture approach to antagonize PAR1

Proteinase-activated receptor-1 (PAR1), triggered by thrombin and other serine proteinases such as tissue kallikrein-4 (KLK4), is a key driver of inflammation, tumor invasiveness and tumor metastasis. The PAR1 transmembrane G-protein-coupled receptor therefore represents an attractive target for the...

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Detalles Bibliográficos
Autores principales: Rabinovitch, Eitan, Mihara, Koishiro, Sananes, Amiram, Zaretsky, Marianna, Heyne, Michael, Shifman, Julia, Aharoni, Amir, Hollenberg, Morley D., Papo, Niv
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352894/
https://www.ncbi.nlm.nih.gov/pubmed/34373558
http://dx.doi.org/10.1038/s41598-021-95666-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352894/
https://www.ncbi.nlm.nih.gov/pubmed/34373558
http://dx.doi.org/10.1038/s41598-021-95666-4

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