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A KLK4 proteinase substrate capture approach to antagonize PAR1

Proteinase-activated receptor-1 (PAR1), triggered by thrombin and other serine proteinases such as tissue kallikrein-4 (KLK4), is a key driver of inflammation, tumor invasiveness and tumor metastasis. The PAR1 transmembrane G-protein-coupled receptor therefore represents an attractive target for the...

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Detalles Bibliográficos
Autores principales:	Rabinovitch, Eitan, Mihara, Koishiro, Sananes, Amiram, Zaretsky, Marianna, Heyne, Michael, Shifman, Julia, Aharoni, Amir, Hollenberg, Morley D., Papo, Niv
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352894/ https://www.ncbi.nlm.nih.gov/pubmed/34373558 http://dx.doi.org/10.1038/s41598-021-95666-4

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