Multifaceted mechanisms mediating cystine starvation-induced ferroptosis

The cyst(e)ine/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis is the most frequently targeted pathway to trigger the ferroptosis cascade and suppress tumor growth. Two recent studies present additional mechanisms underlying cystine starvation-induced ferroptosis apart from impaired GSH synth...

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Detalles Bibliográficos
Autores principales: Shi, Zhennan, Naowarojna, Nathchar, Pan, Zijian, Zou, Yilong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352933/
https://www.ncbi.nlm.nih.gov/pubmed/34373463
http://dx.doi.org/10.1038/s41467-021-25159-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352933/
https://www.ncbi.nlm.nih.gov/pubmed/34373463
http://dx.doi.org/10.1038/s41467-021-25159-5

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