Multifaceted mechanisms mediating cystine starvation-induced ferroptosis

The cyst(e)ine/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis is the most frequently targeted pathway to trigger the ferroptosis cascade and suppress tumor growth. Two recent studies present additional mechanisms underlying cystine starvation-induced ferroptosis apart from impaired GSH synth...

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Autores principales: Shi, Zhennan, Naowarojna, Nathchar, Pan, Zijian, Zou, Yilong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352933/
https://www.ncbi.nlm.nih.gov/pubmed/34373463
http://dx.doi.org/10.1038/s41467-021-25159-5
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author Shi, Zhennan
Naowarojna, Nathchar
Pan, Zijian
Zou, Yilong
author_facet Shi, Zhennan
Naowarojna, Nathchar
Pan, Zijian
Zou, Yilong
author_sort Shi, Zhennan
collection PubMed
description The cyst(e)ine/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis is the most frequently targeted pathway to trigger the ferroptosis cascade and suppress tumor growth. Two recent studies present additional mechanisms underlying cystine starvation-induced ferroptosis apart from impaired GSH synthesis.
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spelling pubmed-83529332021-08-19 Multifaceted mechanisms mediating cystine starvation-induced ferroptosis Shi, Zhennan Naowarojna, Nathchar Pan, Zijian Zou, Yilong Nat Commun Comment The cyst(e)ine/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis is the most frequently targeted pathway to trigger the ferroptosis cascade and suppress tumor growth. Two recent studies present additional mechanisms underlying cystine starvation-induced ferroptosis apart from impaired GSH synthesis. Nature Publishing Group UK 2021-08-09 /pmc/articles/PMC8352933/ /pubmed/34373463 http://dx.doi.org/10.1038/s41467-021-25159-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Comment
Shi, Zhennan
Naowarojna, Nathchar
Pan, Zijian
Zou, Yilong
Multifaceted mechanisms mediating cystine starvation-induced ferroptosis
title Multifaceted mechanisms mediating cystine starvation-induced ferroptosis
title_full Multifaceted mechanisms mediating cystine starvation-induced ferroptosis
title_fullStr Multifaceted mechanisms mediating cystine starvation-induced ferroptosis
title_full_unstemmed Multifaceted mechanisms mediating cystine starvation-induced ferroptosis
title_short Multifaceted mechanisms mediating cystine starvation-induced ferroptosis
title_sort multifaceted mechanisms mediating cystine starvation-induced ferroptosis
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352933/
https://www.ncbi.nlm.nih.gov/pubmed/34373463
http://dx.doi.org/10.1038/s41467-021-25159-5
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AT panzijian multifacetedmechanismsmediatingcystinestarvationinducedferroptosis
AT zouyilong multifacetedmechanismsmediatingcystinestarvationinducedferroptosis

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