TRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation

The cellular NLRP3 protein level is crucial for assembly and activation of the NLRP3 inflammasome. Various posttranslational modifications (PTMs), including phosphorylation and ubiquitination, control NLRP3 protein degradation and inflammasome activation; however, the function of small ubiquitin-lik...

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Detalles Bibliográficos
Autores principales: Qin, Ying, Li, Qi, Liang, Wenbo, Yan, Rongzhen, Tong, Li, Jia, Mutian, Zhao, Chunyuan, Zhao, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352945/
https://www.ncbi.nlm.nih.gov/pubmed/34373456
http://dx.doi.org/10.1038/s41467-021-25033-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8352945/
https://www.ncbi.nlm.nih.gov/pubmed/34373456
http://dx.doi.org/10.1038/s41467-021-25033-4

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