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Alpha-ketoglutarate ameliorates pressure overload-induced chronic cardiac dysfunction in mice

Increasing evidence indicates the involvement of myocardial oxidative injury and mitochondrial dysfunction in the pathophysiology of heart failure (HF). Alpha-ketoglutarate (AKG) is an intermediate metabolite of the tricarboxylic acid (TCA) cycle that participates in different cellular metabolic and...

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Detalles Bibliográficos
Autores principales: An, Dongqi, Zeng, Qingchun, Zhang, Peijian, Ma, Zhuang, Zhang, Hao, Liu, Zuheng, Li, Jiaying, Ren, Hao, Xu, Dingli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353361/
https://www.ncbi.nlm.nih.gov/pubmed/34364218
http://dx.doi.org/10.1016/j.redox.2021.102088