Cargando…

Alpha-ketoglutarate ameliorates pressure overload-induced chronic cardiac dysfunction in mice

Increasing evidence indicates the involvement of myocardial oxidative injury and mitochondrial dysfunction in the pathophysiology of heart failure (HF). Alpha-ketoglutarate (AKG) is an intermediate metabolite of the tricarboxylic acid (TCA) cycle that participates in different cellular metabolic and...

Descripción completa

Detalles Bibliográficos
Autores principales:	An, Dongqi, Zeng, Qingchun, Zhang, Peijian, Ma, Zhuang, Zhang, Hao, Liu, Zuheng, Li, Jiaying, Ren, Hao, Xu, Dingli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353361/ https://www.ncbi.nlm.nih.gov/pubmed/34364218 http://dx.doi.org/10.1016/j.redox.2021.102088

Ejemplares similares

Metformin Increases Cardiac Rupture After Myocardial Infarction via the AMPK-MTOR/PGC-1α Signaling Pathway in Rats with Acute Myocardial Infarction
por: Hua, Jinghai, et al.
Publicado: (2018)

Mitofusin 2 Participates in Mitophagy and Mitochondrial Fusion Against Angiotensin II-Induced Cardiomyocyte Injury
por: Xiong, Wenjun, et al.
Publicado: (2019)

Metformin Collaborates with PINK1/Mfn2 Overexpression to Prevent Cardiac Injury by Improving Mitochondrial Function
por: Ma, Zhuang, et al.
Publicado: (2023)

N-terminal truncated peroxisome proliferator-activated receptor-γ coactivator-1α alleviates phenylephrine-induced mitochondrial dysfunction and decreases lipid droplet accumulation in neonatal rat cardiomyocytes
por: Liu, Zuheng, et al.
Publicado: (2018)

Moderate-Intensity Exercise Affects Gut Microbiome Composition and Influences Cardiac Function in Myocardial Infarction Mice
por: Liu, Zuheng, et al.
Publicado: (2017)

Alpha-ketoglutarate ameliorates age-related osteoporosis via regulating histone methylations
por: Wang, Yuan, et al.
Publicado: (2020)

Mitoquinone ameliorates pressure overload-induced cardiac fibrosis and left ventricular dysfunction in mice
por: Goh, Kah Yong, et al.
Publicado: (2019)

A CRM1 Inhibitor Alleviates Cardiac Hypertrophy and Increases the Nuclear Distribution of NT-PGC-1α in NRVMs
por: Liu, Zuheng, et al.
Publicado: (2019)

Blood pressure trajectories in early adulthood and myocardial structure and function in later life
por: Zhou, Haobin, et al.
Publicado: (2022)

Alpha-Ketoglutarate: Physiological Functions and Applications
por: Wu, Nan, et al.
Publicado: (2016)

Alpha-ketoglutarate for adipose tissue rejuvenation
por: Tian, Qiyu, et al.
Publicado: (2020)

Alpha-ketoglutarate ameliorates abdominal aortic aneurysm via inhibiting PXDN/HOCL/ERK signaling pathways
por: Liu, Junjun, et al.
Publicado: (2022)

The Antioxidative Function of Alpha-Ketoglutarate and Its Applications
por: Liu, Shaojuan, et al.
Publicado: (2018)

The antioxidant compound tert-butylhydroquinone activates Akt in myocardium, suppresses apoptosis and ameliorates pressure overload-induced cardiac dysfunction
por: Zhang, Yongtao, et al.
Publicado: (2015)

Association between urinary biomarkers of polycyclic aromatic hydrocarbons and severe abdominal aortic calcification in adults: data from the National Health and Examination Nutrition Survey
por: Yang, Xi, et al.
Publicado: (2023)

Alpha-ketoglutarate utilization in Saccharomyces cerevisiae: transport, compartmentation and catabolism
por: Zhang, Jinrui, et al.
Publicado: (2020)

Sacubitril/valsartan ameliorates cardiac hypertrophy and preserves diastolic function in cardiac pressure overload
por: Nordén, Einar Sjaastad, et al.
Publicado: (2021)

Thymoquinone ameliorates pressure overload‐induced cardiac hypertrophy by activating the AMPK signalling pathway
por: Chen, Heng, et al.
Publicado: (2021)

Gallic acid improves cardiac dysfunction and fibrosis in pressure overload-induced heart failure
por: Jin, Li, et al.
Publicado: (2018)

Nicotinamide Riboside Alleviates Cardiac Dysfunction and Remodeling in Pressure Overload Cardiac Hypertrophy
por: Ma, Sai, et al.
Publicado: (2021)

Rutaecarpine Ameliorates Pressure Overload Cardiac Hypertrophy by Suppression of Calcineurin and Angiotensin II
por: Li, Shujun, et al.
Publicado: (2021)

Anti-Parstatin Promotes Angiogenesis and Ameliorates Left Ventricular Dysfunction during Pressure Overload
por: Givvimani, Srikanth, et al.
Publicado: (2014)

Celecoxib prevents pressure overload‐induced cardiac hypertrophy and dysfunction by inhibiting inflammation, apoptosis and oxidative stress
por: Zhang, Chi, et al.
Publicado: (2015)

Sodium (±)‐5‐bromo‐2‐(α‐hydroxypentyl) benzoate ameliorates pressure overload‐induced cardiac hypertrophy and dysfunction through inhibiting autophagy
por: Wang, Bo, et al.
Publicado: (2019)

Resveratrol ameliorates cardiac dysfunction induced by pressure overload in rats via structural protection and modulation of Ca(2+) cycling proteins
por: Dong, Qi, et al.
Publicado: (2014)

TRPA1 inhibition ameliorates pressure overload-induced cardiac hypertrophy and fibrosis in mice
por: Wang, Zhen, et al.
Publicado: (2018)

Metabolite alpha-ketoglutarate: a novel target of gasdermin C-dependent pyroptosis
por: Zhang, Yao, et al.
Publicado: (2023)

The physiological metabolite α-ketoglutarate ameliorates osteoarthritis by regulating mitophagy and oxidative stress
por: Liu, Liang, et al.
Publicado: (2023)

Pressure Overload-induced Cardiac Remodeling and Dysfunction in the Absence of Interleukin 6 in Mice
por: Lai, N. Chin, et al.
Publicado: (2012)

Lionheart LincRNA alleviates cardiac systolic dysfunction under pressure overload
por: Kuwabara, Yasuhide, et al.
Publicado: (2020)

Inhibition of Interleukin‐6/glycoprotein 130 signalling by Bazedoxifene ameliorates cardiac remodelling in pressure overload mice
por: Shi, Wei, et al.
Publicado: (2020)

Therapeutic potential of alpha-ketoglutarate against acetaminophen-induced hepatotoxicity in rats
por: Mehra, Lalita, et al.
Publicado: (2016)

Chronic intermittent hypoxia accelerates cardiac dysfunction and cardiac remodeling during cardiac pressure overload in mice and can be alleviated by PHD3 overexpression
por: Xu, Xuan, et al.
Publicado: (2022)

Low-intensity pulsed ultrasound enhances angiogenesis and ameliorates contractile dysfunction of pressure-overloaded heart in mice
por: Ogata, Tsuyoshi, et al.
Publicado: (2017)

Identification of early cardiac dysfunction and heterogeneity after pressure and volume overload in mice by high-frequency echocardiographic strain imaging
por: Xu, Ran, et al.
Publicado: (2023)

The Natural Product Zerumbone Suppresses Pressure Overload-Induced Cardiac Dysfunction by Inhibiting Cardiac Hypertrophy and Fibrosis
por: Tojima, Mikuto, et al.
Publicado: (2021)

The Overexpression of Twinkle Helicase Ameliorates the Progression of Cardiac Fibrosis and Heart Failure in Pressure Overload Model in Mice
por: Tanaka, Atsushi, et al.
Publicado: (2013)

Characteristic Features of Kynurenine Aminotransferase Allosterically Regulated by (Alpha)-Ketoglutarate in Cooperation with Kynurenine
por: Okada, Ken, et al.
Publicado: (2012)

Growth on Alpha-Ketoglutarate Increases Oxidative Stress Resistance in the Yeast Saccharomyces cerevisiae
por: Bayliak, Maria, et al.
Publicado: (2017)

Alpha-ketoglutarate protects Streptomyces coelicolor from visible light-induced phototoxicity
por: Xu, Feng, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_04th70r7jkpn3eofq6f1cvjelu