IL2RA Methylation and Gene Expression in Relation to the Multiple Sclerosis-Associated Gene Variant rs2104286 and Soluble IL-2Rα in CD8(+) T Cells

CD8(+) T cells are involved in the pathogenesis of multiple sclerosis (MS). The interleukin-2 receptor α (IL-2Rα) is important for CD8(+) T cell function, and single nucleotide polymorphisms (SNPs) in the IL2RA gene encoding IL-2Rα increase the risk of MS. Therefore, in isolated CD8(+) T cells we in...

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Detalles Bibliográficos
Autores principales: Buhelt, Sophie, Laigaard, Hannah-Marie, von Essen, Marina Rode, Ullum, Henrik, Oturai, Annette, Sellebjerg, Finn, Søndergaard, Helle Bach
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353370/
https://www.ncbi.nlm.nih.gov/pubmed/34386002
http://dx.doi.org/10.3389/fimmu.2021.676141

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353370/
https://www.ncbi.nlm.nih.gov/pubmed/34386002
http://dx.doi.org/10.3389/fimmu.2021.676141

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