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IL2RA Methylation and Gene Expression in Relation to the Multiple Sclerosis-Associated Gene Variant rs2104286 and Soluble IL-2Rα in CD8(+) T Cells
CD8(+) T cells are involved in the pathogenesis of multiple sclerosis (MS). The interleukin-2 receptor α (IL-2Rα) is important for CD8(+) T cell function, and single nucleotide polymorphisms (SNPs) in the IL2RA gene encoding IL-2Rα increase the risk of MS. Therefore, in isolated CD8(+) T cells we in...
Autores principales: | Buhelt, Sophie, Laigaard, Hannah-Marie, von Essen, Marina Rode, Ullum, Henrik, Oturai, Annette, Sellebjerg, Finn, Søndergaard, Helle Bach |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353370/ https://www.ncbi.nlm.nih.gov/pubmed/34386002 http://dx.doi.org/10.3389/fimmu.2021.676141 |
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