Generation of Novel Human Red Blood Cell-Bearing Humanized Mouse Models Based on C3-Deficient NOG Mice

Despite recent advances in immunodeficient mouse models bearing human red blood cells (hRBCs), the elimination of circulating hRBCs by residual innate immune systems remains a significant challenge. In this study, we evaluated the role of mouse complement C3 in the elimination of circulating hRBCs b...

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Detalles Bibliográficos
Autores principales: Yamaguchi, Takuya, Katano, Ikumi, Otsuka, Iyo, Ito, Ryoji, Mochizuki, Misa, Goto, Motohito, Takahashi, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353390/
https://www.ncbi.nlm.nih.gov/pubmed/34386001
http://dx.doi.org/10.3389/fimmu.2021.671648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353390/
https://www.ncbi.nlm.nih.gov/pubmed/34386001
http://dx.doi.org/10.3389/fimmu.2021.671648

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