SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis

BACKGROUND: Loss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressive paralysis and death. Dysregulation of thousands of RNA molecules with roles in multiple cellular pathways hinders the identification of ALS-causing alterations over downstream changes secondary to the neuro...

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Detalles Bibliográficos
Autores principales: Castelli, Lydia M., Cutillo, Luisa, Souza, Cleide Dos Santos, Sanchez-Martinez, Alvaro, Granata, Ilaria, Lin, Ya-Hui, Myszczynska, Monika A., Heath, Paul R., Livesey, Matthew R., Ning, Ke, Azzouz, Mimoun, Shaw, Pamela J., Guarracino, Mario R., Whitworth, Alexander J., Ferraiuolo, Laura, Milo, Marta, Hautbergue, Guillaume M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353793/
https://www.ncbi.nlm.nih.gov/pubmed/34376242
http://dx.doi.org/10.1186/s13024-021-00475-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353793/
https://www.ncbi.nlm.nih.gov/pubmed/34376242
http://dx.doi.org/10.1186/s13024-021-00475-y

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