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NMDAR modulators as rapid antidepressants: Converging and distinct signaling mechanisms

Dysregulation of the glutamatergic system underlies the pathophysiology of depression. Both negative and positive modulation of NMDARs exert rapid and sustained antidepressant effects by reversing the dysregulated glutamatergic system. Research in the past decades has identified key signaling pathwa...

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Detalles Bibliográficos
Autores principales: Lee, Boyoung, Pothula, Santosh, Duman, Ronald S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353843/
https://www.ncbi.nlm.nih.gov/pubmed/34381955
http://dx.doi.org/10.15761/icm.1000173