NMDAR modulators as rapid antidepressants: Converging and distinct signaling mechanisms

Dysregulation of the glutamatergic system underlies the pathophysiology of depression. Both negative and positive modulation of NMDARs exert rapid and sustained antidepressant effects by reversing the dysregulated glutamatergic system. Research in the past decades has identified key signaling pathwa...

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Autores principales: Lee, Boyoung, Pothula, Santosh, Duman, Ronald S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353843/
https://www.ncbi.nlm.nih.gov/pubmed/34381955
http://dx.doi.org/10.15761/icm.1000173
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author Lee, Boyoung
Pothula, Santosh
Duman, Ronald S
author_facet Lee, Boyoung
Pothula, Santosh
Duman, Ronald S
author_sort Lee, Boyoung
collection PubMed
description Dysregulation of the glutamatergic system underlies the pathophysiology of depression. Both negative and positive modulation of NMDARs exert rapid and sustained antidepressant effects by reversing the dysregulated glutamatergic system. Research in the past decades has identified key signaling pathways activated by these rapid acting antidepressants. Here, we review the converging signaling mechanisms shared by rapid acting antidepressants and discuss the recent progress on distinct actions of NMDAR antagonists and NMDAR positive modulators to trigger rapid antidepressant actions.
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spelling pubmed-83538432021-08-10 NMDAR modulators as rapid antidepressants: Converging and distinct signaling mechanisms Lee, Boyoung Pothula, Santosh Duman, Ronald S Integr Clin Med Article Dysregulation of the glutamatergic system underlies the pathophysiology of depression. Both negative and positive modulation of NMDARs exert rapid and sustained antidepressant effects by reversing the dysregulated glutamatergic system. Research in the past decades has identified key signaling pathways activated by these rapid acting antidepressants. Here, we review the converging signaling mechanisms shared by rapid acting antidepressants and discuss the recent progress on distinct actions of NMDAR antagonists and NMDAR positive modulators to trigger rapid antidepressant actions. 2020-02-04 2020-06 /pmc/articles/PMC8353843/ /pubmed/34381955 http://dx.doi.org/10.15761/icm.1000173 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Article
Lee, Boyoung
Pothula, Santosh
Duman, Ronald S
NMDAR modulators as rapid antidepressants: Converging and distinct signaling mechanisms
title NMDAR modulators as rapid antidepressants: Converging and distinct signaling mechanisms
title_full NMDAR modulators as rapid antidepressants: Converging and distinct signaling mechanisms
title_fullStr NMDAR modulators as rapid antidepressants: Converging and distinct signaling mechanisms
title_full_unstemmed NMDAR modulators as rapid antidepressants: Converging and distinct signaling mechanisms
title_short NMDAR modulators as rapid antidepressants: Converging and distinct signaling mechanisms
title_sort nmdar modulators as rapid antidepressants: converging and distinct signaling mechanisms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353843/
https://www.ncbi.nlm.nih.gov/pubmed/34381955
http://dx.doi.org/10.15761/icm.1000173
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