Cathepsin H deficiency decreases hypoxia-ischemia-induced hippocampal atrophy in neonatal mice through attenuated TLR3/IFN-β signaling

BACKGROUND: Cathepsin H (CatH) is a lysosomal cysteine protease with a unique aminopeptidase activity. Its expression level is increased in activated immune cells including dendritic cells, macrophages, and microglia. We have previously reported that CatH deficiency impairs toll-like receptor 3 (TLR...

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Detalles Bibliográficos
Autores principales: Ni, Junjun, Zhao, Juan, Zhang, Xinwen, Reinheckel, Thomas, Turk, Vito, Nakanishi, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353845/
https://www.ncbi.nlm.nih.gov/pubmed/34376208
http://dx.doi.org/10.1186/s12974-021-02227-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353845/
https://www.ncbi.nlm.nih.gov/pubmed/34376208
http://dx.doi.org/10.1186/s12974-021-02227-7

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