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Cathepsin H deficiency decreases hypoxia-ischemia-induced hippocampal atrophy in neonatal mice through attenuated TLR3/IFN-β signaling
BACKGROUND: Cathepsin H (CatH) is a lysosomal cysteine protease with a unique aminopeptidase activity. Its expression level is increased in activated immune cells including dendritic cells, macrophages, and microglia. We have previously reported that CatH deficiency impairs toll-like receptor 3 (TLR...
Autores principales: | Ni, Junjun, Zhao, Juan, Zhang, Xinwen, Reinheckel, Thomas, Turk, Vito, Nakanishi, Hiroshi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353845/ https://www.ncbi.nlm.nih.gov/pubmed/34376208 http://dx.doi.org/10.1186/s12974-021-02227-7 |
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