Discovery of Small Molecule Entry Inhibitors Targeting the Fusion Peptide of SARS-CoV-2 Spike Protein

[Image: see text] SARS-CoV-2 entry into host cells relies on the spike (S) protein binding to the human ACE2 receptor. In this study, we investigated the structural dynamics of the viral S protein at the fusion peptide (FP) domain and small molecule binding for therapeutics development. Following co...

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Detalles Bibliográficos
Autores principales: Hu, Xin, Chen, Catherine Z., Xu, Miao, Hu, Zongyi, Guo, Hui, Itkin, Zina, Shinn, Paul, Ivin, Parker, Leek, Madeleine, Liang, T. Jake, Shen, Min, Zheng, Wei, Hall, Matthew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353886/
https://www.ncbi.nlm.nih.gov/pubmed/34394844
http://dx.doi.org/10.1021/acsmedchemlett.1c00263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353886/
https://www.ncbi.nlm.nih.gov/pubmed/34394844
http://dx.doi.org/10.1021/acsmedchemlett.1c00263

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