LDH‐A negatively regulates dMMR in colorectal cancer

Although immune checkpoint inhibitors (ICIs) have achieved unprecedented success in dMMR tumors, pMMR tumors accounting for 85% of colorectal cancer (CRC) cases remain unresponsive. Lactate dehydrogenase A (LDH‐A) is the rate‐limiting enzyme that catalyzes the transformation of pyruvate to lactate i...

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Detalles Bibliográficos
Autores principales: Zhang, Yongjie, Li, Juan, Wang, Bo, Chen, Ting, Chen, Yun, Ma, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353898/
https://www.ncbi.nlm.nih.gov/pubmed/34110068
http://dx.doi.org/10.1111/cas.15020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353898/
https://www.ncbi.nlm.nih.gov/pubmed/34110068
http://dx.doi.org/10.1111/cas.15020

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