VLX1570 induces apoptosis through the generation of ROS and induction of ER stress on leukemia cell lines

A novel proteasome deubiquitinase inhibitor, VLX1570, has been highlighted as a promising therapeutic agent mainly for lymphoid neoplasms and solid tumors. We examined in vitro effects of VLX1570 on eight myeloid and three lymphoid leukemia cell lines. From cell culture studies, 10 out of 11 cell li...

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Detalles Bibliográficos
Autores principales: Kurozumi, Nami, Tsujioka, Takayuki, Ouchida, Mamoru, Sakakibara, Kanae, Nakahara, Takako, Suemori, Shin‐ichiro, Takeuchi, Masaki, Kitanaka, Akira, Shibakura, Misako, Tohyama, Kaoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353915/
https://www.ncbi.nlm.nih.gov/pubmed/34032336
http://dx.doi.org/10.1111/cas.14982

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353915/
https://www.ncbi.nlm.nih.gov/pubmed/34032336
http://dx.doi.org/10.1111/cas.14982

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