Cargando…
Azithromycin enhances the cytotoxicity of DNA‐damaging drugs via lysosomal membrane permeabilization in lung cancer cells
Cancer cells use autophagy for growth, survival, and cytoprotection from chemotherapy. Therefore, autophagy inhibitors appear to be good candidates for cancer treatment. Our group previously reported that macrolide antibiotics, especially azithromycin (AZM), have potent autophagy inhibitory effects,...
Autores principales: | Toriyama, Kazutoshi, Takano, Naoharu, Kokuba, Hiroko, Kazama, Hiromi, Moriya, Shota, Hiramoto, Masaki, Abe, Shinji, Miyazawa, Keisuke |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353917/ https://www.ncbi.nlm.nih.gov/pubmed/34051014 http://dx.doi.org/10.1111/cas.14992 |
Ejemplares similares
-
Macrolide antibiotics enhance the antitumor effect of lansoprazole resulting in lysosomal membrane permeabilization-associated cell death
por: Takeda, Atsuo, et al.
Publicado: (2020) -
Abemaciclib induces atypical cell death in cancer cells characterized by formation of cytoplasmic vacuoles derived from lysosomes
por: Hino, Hirotsugu, et al.
Publicado: (2020) -
Targeted disruption of GAK stagnates autophagic flux by disturbing lysosomal dynamics
por: Miyazaki, Masaya, et al.
Publicado: (2021) -
Comparison of autophagy inducibility in various tyrosine kinase inhibitors and their enhanced cytotoxicity via inhibition of autophagy in cancer cells in combined treatment with azithromycin
por: Tanaka, Hideki, et al.
Publicado: (2020) -
p53 regulates lysosomal membrane permeabilization as well as cytoprotective autophagy in response to DNA-damaging drugs
por: Yamashita, Gai, et al.
Publicado: (2022)