Enhancement of epidermal growth factor receptor antibody tumor immunotherapy by glutaminyl cyclase inhibition to interfere with CD47/signal regulatory protein alpha interactions

Integrin associated protein (CD47) is an important target in immunotherapy, as it is expressed as a “don't eat me” signal on many tumor cells. Interference with its counter molecule signal regulatory protein alpha (SIRPα), expressed on myeloid cells, can be achieved with blocking Abs, but also...

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Detalles Bibliográficos
Autores principales: Baumann, Niklas, Rösner, Thies, Jansen, J. H. Marco, Chan, Chilam, Marie Eichholz, Klara, Klausz, Katja, Winterberg, Dorothee, Müller, Kristina, Humpe, Andreas, Burger, Renate, Peipp, Matthias, Schewe, Denis M., Kellner, Christian, Leusen, Jeanette H. W., Valerius, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353920/
https://www.ncbi.nlm.nih.gov/pubmed/34058788
http://dx.doi.org/10.1111/cas.14999

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353920/
https://www.ncbi.nlm.nih.gov/pubmed/34058788
http://dx.doi.org/10.1111/cas.14999

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