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Synthetic Peptides That Antagonize the Angiotensin-Converting Enzyme-2 (ACE-2) Interaction with SARS-CoV-2 Receptor Binding Spike Protein
[Image: see text] The SARS-CoV-2 viral spike protein S receptor-binding domain (S-RBD) binds ACE2 on host cells to initiate molecular events, resulting in intracellular release of the viral genome. Therefore, antagonists of this interaction could allow a modality for therapeutic intervention. Peptid...
Autores principales: | Sadremomtaz, Afsaneh, Al-Dahmani, Zayana M., Ruiz-Moreno, Angel J., Monti, Alessandra, Wang, Chao, Azad, Taha, Bell, John C., Doti, Nunzianna, Velasco-Velázquez, Marco A., de Jong, Debora, de Jonge, Jørgen, Smit, Jolanda, Dömling, Alexander, van Goor, Harry, Groves, Matthew R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American
Chemical
Society
2021
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8353989/ https://www.ncbi.nlm.nih.gov/pubmed/34328726 http://dx.doi.org/10.1021/acs.jmedchem.1c00477 |
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