Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination

SPT6 is a histone chaperone that tightly binds RNA polymerase II (RNAPII) during transcription elongation. However, its primary role in transcription is uncertain. We used targeted protein degradation to rapidly deplete SPT6 in human cells and analyzed defects in RNAPII behavior by a multi-omics app...

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Detalles Bibliográficos
Autores principales: Narain, Ashwin, Bhandare, Pranjali, Adhikari, Bikash, Backes, Simone, Eilers, Martin, Dölken, Lars, Schlosser, Andreas, Erhard, Florian, Baluapuri, Apoorva, Wolf, Elmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354102/
https://www.ncbi.nlm.nih.gov/pubmed/34233157
http://dx.doi.org/10.1016/j.molcel.2021.06.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354102/
https://www.ncbi.nlm.nih.gov/pubmed/34233157
http://dx.doi.org/10.1016/j.molcel.2021.06.016

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