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Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination
SPT6 is a histone chaperone that tightly binds RNA polymerase II (RNAPII) during transcription elongation. However, its primary role in transcription is uncertain. We used targeted protein degradation to rapidly deplete SPT6 in human cells and analyzed defects in RNAPII behavior by a multi-omics app...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8354102/ https://www.ncbi.nlm.nih.gov/pubmed/34233157 http://dx.doi.org/10.1016/j.molcel.2021.06.016 |